Monument to Don Carlos IV, Plaza McKinley, Manila, Philippines.
This famous monument located in Manila honors Don Carlos IV of Spain(King Charles IV) for his contributions to smallpox vaccinations throughout the Philippines
On September 1, 1803, King Charles IV of Spain issued a royal decree to his domains announcing a smallpox expedition that would vaccinate the masses for free. The smallpox expedition arrived in Manila in April 1805. Due to the transportation difficulties with live vaccines, 25 Mexican orphans were used as living repositories.